Gain insights into the diagnosis and treatment of one of the most widespread forms of human suffering: depression. We will be using psychiatric differential diagnosis of depression from the DSM V & NIH knowledge base, joined with the deep Chinese scientific medical model of body, mind, and shen. When observing depression and its symptoms, it is strikingly apparent that both the root of the suffering and the source for healing can be examined from five types referring to Wu Zhi (five wills), Wu Shen (five spirits) and the five elements. On each meridian are special points that either have shen or tian (heaven) in their name, or have a special influence on the mind and shen. This lecture is a presentation of clinical cases and discussion of special ancient observational techniques for evaluating the shen and understanding the innermost core concerns necessary to uncover the true imbalances that are the cause of the symptoms and signs. Chinese medicine uses the patient’s own healing abilities to cure themselves; therefore, the more precise the diagnosis, the more accurate the choice of points that can create this type of transformation–and the better we can enhance patients’ strengths and potential to harness their self-healing capacity and achieve a positive outcome.