During the last century, Chinese medical thinking has become strongly influenced by the parameters of Western medicine. One aspect of this influence is a disproportionate focus on the organ networks of the post-natal realm that govern the material processes of the body, especially the Spleen and Stomach. However, when dealing with more serious and complex disorders it is often the more “mysterious” aspects of Chinese medicine—e.g., the vacuous Triple Warmer system and the associated concept of Ministerial Fire—that are most relevant in the process of diagnosis and treatment. This presentation provides a comprehensive exploration of the concept of Ministerial Fire and its acute relevance for the approach to recalcitrant diseases including COVID-19.