Neil Theise’s book Notes on Complexity, which Deepak Chopra said “will change the way you understand yourself and the universe,” is a startling introduction to the science of how complex systems behave that explains the interconnectedness of all things. Notes on Complexity encourages us to shift from a narrow, individualistic worldview to one that recognizes the universe as an interconnected, living system greater than the sum of its parts. Neil Theise, drawing on his background as a physician, scientist, and philosopher, explores the frontiers of human knowledge while revitalizing our appreciation of the everyday. His research in liver pathology, which revealed new understandings about interstitial connections in Western physiology, builds bridges between Eastern and Western thought with implications for cross-disciplinary communication and practical applications in medicine and beyond.