We will discuss the treatment of infection and inflammation from both Western and Chinese medicine perspectives. Infection and inflammation are two disorders that are different yet commonly occur together. From the Chinese medicine perspective, both are considered heat, although pathology and treatment strategies are quite different. “Heat” by itself is too general to describe the pathology of disease, as heat may present in fever, infection, inflammation, allergy, autoimmune disease, and more. Similarly, “heat-clearing” is also vague, and additional information on its pharmacology is beneficial, such as antipyretic, antibiotic (antiviral, antibacterial, antifungal), antiallergic, or anti-inflammatory effects. This seminar provides valuable information to accurately diagnose the disease and select the suitable herbal treatment based on both Chinese herbology and Western pharmacology.