The thoracolumbar junction (TLJ) is a region of the spine that consists of T12-L2. From this region many key joints, muscles and viscera are innervated. The TLJ can become dysfunctional as a unit, contribute to painful trigger point formation, and refer pain to the low back, pelvis, and groin. We will explore the neural, myofascial, and channel anatomy of this region and look at common pain patterns that frequently present in the clinic. You will gain a better ability to recognize, assess, and treat this intriguing area of the body.